Edward, Alphonse and Winry head south in search of Izumi Curtis, the master alchemist who taught the two brothers the art. An encounter with a pickpocket in Rush Valley starts them down a different path in search of an auto-mail blacksmith who Winry declares is the best he's ever seen.

As young boys, Edward & Alphonse Elric dabbled in alchemy to try to resurrect their dead mother. As a result, Ed lost one arm and one leg, while Al lost his entire body and had his spirit sealed into a suit of armor. Now, they are searching for the fabled Philosopher's Stone to restore what they've lost.